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ドコサヘキサエノ酸補給とアルツハイマー病における認知機能低下:ランダム化試験
Joseph F Quinn1, Rema Raman, Ronald G Thomas
1Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA. quinnj@ohsu.edu
JAMA
|November 4, 2010
まとめ
ドコサヘキサエノ酸 (DHA) 補給は,軽度から中度までアルツハイマー病の患者に認知または機能的低下を遅らせることはありませんでした. この18ヶ月の臨床試験では,認知スコアや脳縮率に有益な効果は認められなかった.
科学分野:
- 神経科学は神経科学である.
- 栄養科学とは,栄養科学である.
- ゲロントロジーはゲロントロジーの学科です.
背景:
- ドコサヘキサエノ酸 (DHA) は,脳に豊富に存在する重要なオメガ3脂肪酸です.
- 疫学および動物の研究は,DHAがアルツハイマー病のリスクと病理学を減らす可能性があることを示唆しています.
- 既存のアルツハイマー病の管理におけるDHA補給の役割は,依然として調査中です.
研究 の 目的:
- アルツハイマー病患者の認知および機能的低下を遅らせるDHA補給の有効性を評価する.
- 軽度から中等度のアルツハイマー病患者の脳縮率に対するDHAの影響を評価する.
主な方法:
- アルツハイマー病の軽度から中度まで402人の参加者を含むランダム化,ダブルブラインド,プラセボ対照試験.
- 参加者は1日2gの藻類DHAまたは18ヶ月間プラセボを投与されました.
- 認知機能 (ADAS-cog),機能的状態 (CDRの箱の和),脳縮 (MRI) が,主な結果指標でした.
主要な成果:
- DHAサプリメントは,認知機能低下の速度を遅らせるのに有意な効果を示さなかった (ADAS-cogスコア).
- CDRの箱の合計で測定された機能的低下も,DHA治療によって有意に影響されませんでした.
- ボリュメトリックMRIは,DHAとプラセボのグループ間の脳縮率の違いを示さなかった.
結論:
- DHAの経口補給は,軽度から中等度のアルツハイマー病患者の認知機能や機能低下を遅らせるようには見えません.
- これらの発見は,この集団におけるアルツハイマー病の治療薬としてDHAの使用を支持しません.
- 更に,神経変性疾患におけるDHA介入のための異なる用量,期間,または患者集団を調査する研究が進められます.
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