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Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...

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Updated: Jun 7, 2026

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

超分子バランス:弱相互作用を拡大するために協力性を利用する.

Mihaela Roman1, Caroline Cannizzo, Thomas Pinault

  • 1Université Claude Bernard-Lyon 1, ICBMS-UMR 5246, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne cedex, France.

Journal of the American Chemical Society
|November 6, 2010
PubMed
まとめ

研究者は,弱い超分子相互作用の微妙な変化を検出するための敏感な方法を開発しました. この技術は,協力的な分子プラットフォームと温度スキャンを使用して,60J/molほどの相互作用の違いを明らかにします.

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Synthesis and Characterization of Supramolecular Colloids
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Synthesis and Characterization of Supramolecular Colloids

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Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

関連する実験動画

Last Updated: Jun 7, 2026

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
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Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

科学分野:

  • 超分子化学 超分子化学
  • 物理化学 物理化学
  • 化学生物学 化学生物学とは

背景:

  • 弱い超分子相互作用の正確な特徴付けは,触媒,結晶工学,リガンド結合,タンパク質折り畳みなどの分野において極めて重要です.
  • 現在の方法は,溶液中のこれらの相互作用のわずかな変化を検出する敏感度が欠けていることが多い.

研究 の 目的:

  • 溶液中の弱い超分子相互作用を検知するための,著しくより敏感な方法を開発する.
  • 微妙な相互作用エネルギー差異を検出するための協力的な超分子プラットフォームの有用性を実証する.

主な方法:

  • 理論的および実験的アプローチを組み合わせたアプローチが採用されました.
  • 非常に協力的な構成移行を特徴とする超分子プラットフォームが設計されました.
  • 温度スキャン実験は,分子改変時にプラットフォームの移行の混乱を監視するために使用されました.

主要な成果:

  • 開発された方法は,相互作用の差異を60J/molまで検出することに成功しました.
  • プラットフォームの感度により,ステリック排斥効果 (ビニール対アルキル群) と溶解効果の差異化が可能になりました.

結論:

  • 溶液中の弱い超分子相互作用を研究するための新しい,非常に敏感な方法が確立されました.
  • 協力的な超分子プラットフォームアプローチは,微妙な分子間力の定量分析のための強力なツールを提供します.
  • このテクニックは,分子認識と自己組み立てプロセスを理解するための幅広い意味を持つ.