中枢神経系の推定T細胞腫瘍遺伝子のセグメンタルおよび発達的調節
J M Greenberg1, T Boehm, M V Sofroniew
1Laboratory of Molecular Biology, Cambridge, UK.
Nature
|March 8, 1990
まとめ
この研究は,T細胞腫瘍における11p15遺伝子 (Ttg) を特定しています. マウスの発達中の脳におけるその発現は,その腫瘍性機能とは異なる神経発達における役割を示唆している.
科学分野:
- 遺伝学 遺伝学とは
- 発達生物学 発達生物学とは
- 神経科学は神経科学である.
背景:
- プロトオンコゲンは通常,細胞増殖を調節する.
- いくつかの原発性腫瘍遺伝子は,細胞の分化に役割を果たす可能性があります.
- 11p15遺伝子 (Ttg) は,トランスロケーション t ((11;14)) 経由でT細胞腫瘍の病原化に関与しています.
研究 の 目的:
- 11p15遺伝子 (Ttg) の正常な機能を調査する.
- 発達中の11p15遺伝子の発現パターンを決定する.
主な方法:
- 11p15プロモーターとlacZ.の融合構造を持つトランスジェニックマウスを利用した.
- 発達中のマウスの後頭脳と中枢神経系における遺伝子発現パターンを分析した.
主要な成果:
- 11p15遺伝子は,発達中の後脳のロンボメアでセグメント特異的な発現を示しています.
- 後の発達段階では,中枢神経系内のポストミトス神経細胞において,より広範で,地域的に制限された発現を示します.
- 表現パターンは発達的に規制され,セグメント的に制限されます.
結論:
- 11p15遺伝子 (Ttg) は,中枢神経系で発達的に調節され,発現します.
- その正常な機能は,T細胞腫瘍における腫瘍学的役割とは分離して,ニューロン発達の過程にあるようです.
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