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Updated: Aug 9, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
13:55

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

第2のB細胞特異増強剤3'は,免疫グロブリン重鎖ロカスである

S Pettersson1, G P Cook, M Brüggemann

  • 1Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Nature
|March 8, 1990
PubMed
まとめ

研究者らは,ネズミの免疫グロブリン重鎖 (IgH) の3'端にある,B細胞特異の新たな強化要素を発見した. この発見は,免疫グロブリン遺伝子がどのように調節されるかを再評価することを示唆し,特定のがんにおけるc-myc遺伝子活性化を説明する可能性がある.

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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches09:35

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