フルクトーゼが豊富な飲料と女性における痛風のリスク
Hyon K Choi1, Walter Willett, Gary Curhan
1Section of Rheumatology and Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany St, Ste 200, Boston, MA 02118, USA. hchoius@bu.edu
JAMA
|November 12, 2010
まとめ
糖分を添加したソーダやオレンジジュースなどのフルークトーゼに富んだ飲料を摂取すると,女性では痛風のリスクが増加します. これらの飲料の摂取量の増加は,痛風の発生率の有意に増加と相関しており,痛風の発症における食事要因を強調しています.
科学分野:
- エピデミオロジー エピデミオロジー
- 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
- レウマトロジーの病理学
背景:
- 糖分を添加したソーダやオレンジジュースを含むフルークトーゼに富んだ飲料は,血清尿酸レベルを上昇させることが知られている.
- 尿酸の上昇は,痛風を発症する危険因子です.
- 果糖飲料の消費と痛風の発生を関連付ける見通しデータは限られている.
研究 の 目的:
- フルクトーゼに富んだ飲料の摂取とフルクトーゼと痛風の発症リスクとの関連を調査する.
- この研究は,多くの女性を対象に実施された.
主な方法:
- 米国での22年間の前向きなコホート研究 (1984-2006) の看護師の健康研究 (Nurses' Health Study) のデータを活用した.
- 78,906人の女性を対象に,痛風の既往歴のない女性を対象にしました.
- 食品摂取頻度に関する検証されたアンケートを使用して,飲料と果糖の摂取量を評価した.
主要な成果:
- 22年間にわたり,痛風の発生例が778件確認されました.
- 糖分を添加したソーダの消費量の増加は,より高い痛風リスクと独立して関連していた (RR ≥2回/日: 2.39).
- オレンジジュースの摂取は,痛風のリスクの増加と有意な関連性も示した (RRは≥2回/日:2.42).
- 総果糖摂取量の増加は,痛風のリスクの増加と関連していた (上位5分の1のRRは1.62).
- ダイエット・ソフトドリンクは,痛風のリスクと関連性がないことが示されました.
結論:
- フルクトーゼに富んだ飲料の消費は,女性における発病性痛風のリスクの増加と関連しています.
- この関連は明らかですが,女性における痛風の発生率が低いため,全体的な人口の貢献は控えめかもしれません.
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