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Updated: Jun 6, 2026

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

Tsix調節と多能性の分子結合

Pablo Navarro1, Andrew Oldfield, Julie Legoupi

  • 1Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France. pablo.navarro@ed.ac.uk

Nature
|November 19, 2010
PubMed
まとめ

多能性因子であるNanog,Oct4,およびSox2はXistを抑制し,Klf4,c-Myc,およびRex1はTsixを活性化させ,X染色体の不活性化再プログラムと胚性幹細胞における多能性を調整する.

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Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome09:39

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

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