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Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Dry Friction01:30

Dry Friction

Dry friction occurs between two solid surfaces in contact as they attempt to move relative to one another. In daily life, dry friction is encountered in various forms, such as when walking on the ground, sliding an object across a table, or rubbing hands together. Despite its ubiquity, the underlying mechanisms behind dry friction are not readily visible.
To illustrate this concept, imagine a wooden crate resting on a rough, non-uniform horizontal surface. When an external force is applied to...
Rolling With Slipping01:14

Rolling With Slipping

Rolling with slipping is a physical phenomenon that occurs when a rolling object experiences both rotational and linear motion but also experiences frictional forces that cause slipping. This phenomenon can occur in various situations, such as when a tire rolls on a wet road or a ball rolls on a rough surface.
An object's rolling motion is characterized by its rotation around its axis, while linear motion refers to the object's translational motion along a surface. Frictional forces can affect...
Shearing Stress01:18

Shearing Stress

Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section.
The average shearing stress can be calculated by dividing the shear by the area of the cross-section.
Wood Surfacing01:14

Wood Surfacing

Wood surfacing is a critical finishing process designed to smoothen the wood surface, enhance its dimensional accuracy, and make handling safer. This process compensates for potential shrinkage during the seasoning phase by marginally increasing the wood dimensions before surfacing. It also helps correct some distortions that may occur as the wood dries.
The equipment used in the surfacing process is a plane equipped with rotating blades. This tool efficiently smoothens the wood surface and can...

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Updated: May 7, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

ERのシーツは,荒らされてしまう.

Charles Barlowe1

  • 1Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. charles.barlowe@dartmouth.edu

Cell
|November 30, 2010
PubMed
まとめ

エンドプラズマ網膜 (ER) のシート構造を形成するタンパク質は,リボソームとの関連によって強化されます. 曲線誘発タンパク質は,ER膜シートの縁に存在します.

科学分野:

  • 細胞生物学 細胞生物学
  • 分子生物学は分子生物学である.
  • バイオケミストリー バイオケミストリー

背景:

  • エンドプラズマ網膜 (ER) 膜は,複雑な管状およびシート構造を形成します.
  • ER膜組織を制御する分子機構は完全に理解されていません.

研究 の 目的:

  • ER膜をシートやチューブルに形作るタンパク質を研究する.
  • ER内のシートおよび曲線誘発タンパク質の局所化と機能を理解する.

主な方法:

  • タンパク質の局所化を視覚化するための免疫光顕微鏡.
  • タンパク質とタンパク質の相互作用を研究するための生化学的測定法.
  • 異なるER膜ドメインを分離するために細胞分断.

主要な成果:

  • Climp-63のようなシート誘導タンパク質は,膜に結合したリボソームと結合しているため,粗いERに集中しています.
  • 曲線誘発タンパク質は,ER膜シートの高度に曲げられた縁に特異的に局所されています.
  • この差異的な局所化は,ER膜形態発生の調整されたメカニズムを示唆する.

結論:

さらに関連する動画

Exfoliation and Analysis of Large-area, Air-Sensitive Two-Dimensional Materials
10:18

Exfoliation and Analysis of Large-area, Air-Sensitive Two-Dimensional Materials

Published on: January 5, 2019

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes
08:32

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes

Published on: June 30, 2019

関連する実験動画

Last Updated: May 7, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Exfoliation and Analysis of Large-area, Air-Sensitive Two-Dimensional Materials
10:18

Exfoliation and Analysis of Large-area, Air-Sensitive Two-Dimensional Materials

Published on: January 5, 2019

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes
08:32

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes

Published on: June 30, 2019

  • リボソーム結合は,シート形成タンパク質を粗いERに集中させる重要な要因です.
  • 異なるタンパク質集団が,ERシートとその曲がった縁の形成を調節する.
  • これらの発見は,ER構造の形成を駆動する分子機構に関する新しい洞察を提供します.