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Updated: Jun 6, 2026

A Fluorescent Screening Assay for Identifying Modulators of GIRK Channels
05:31

A Fluorescent Screening Assay for Identifying Modulators of GIRK Channels

Published on: April 24, 2012

Gタンパク質と結合した受容体キナーゼによるGIRKチャネル機能の非酵素的急速制御

Adi Raveh1, Ayelet Cooper, Liora Guy-David

  • 1Department Biological Chemistry Weizmann Institute of Science, Rehovot, Israel.

Cell
|November 30, 2010
PubMed
まとめ

GPCRキナーゼ (GRKs) は,キナーゼ活動とは関係なく,Gタンパク質サブユニットを結合することによって,Gタンパク質結合カリウムチャネル (GIRKs) を迅速に無感化します. このメカニズムは,Gタンパク質結合受容体シグナル伝達の刺激特異的な調節を提供します.

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