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Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
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癌の誘発因子を明らかにするための統合的アプローチ

Uri David Akavia1, Oren Litvin, Jessica Kim

  • 1Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

Cell
|December 7, 2010
PubMed
まとめ

この研究は,コピー番号と遺伝子発現データを統合することによって,がんを誘発する遺伝的変異を特定するためのコンピューティングフレームワークを導入しています. このアプローチは,メラノーマの主要な要因を正確に特定し,新しい依存性を明らかにし,新しい治療目標を示唆しました.

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