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Updated: Mar 29, 2026

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CENP-Bは,レトロトランポゾンLTRによって停止された複製フォークでゲノムの完全性を保ちます

Mikel Zaratiegui1, Matthew W Vaughn, Danielle V Irvine

  • 1Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

Nature
|December 15, 2010
PubMed
まとめ

セントロメア結合タンパク質B (CENP-B) は,LTRレトロトランポゾンを通してDNA複製フォークの進行を促進します. CENP-Bの喪失は,複製フォークの阻害によりゲノムの不安定性を引き起こし,ゲノム安定性の維持におけるその役割を強調します.

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