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Time-Resolved Fluorescence Anisotropy from Single Molecules for Characterizing Local Flexibility in Biomolecules
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ホットスポットの適切なマッピングには,完全なタンパク質の柔軟性が不可欠です.

Katrina W Lexa1, Heather A Carlson

  • 1Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1065, United States.

Journal of the American Chemical Society
|December 17, 2010
PubMed
まとめ

構造ベースの薬物設計のための正確なホットスポットマッピングには,タンパク質の柔軟性を考慮する必要があります. シミュレーションにより,硬いタンパク質ではなく,完全に柔軟なタンパク質のみが,偽の最小値を除去することによって結合部位を正しく識別することが明らかになった.

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