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Updated: Jun 6, 2026

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ATMダメージ応答とXLF修復因子は,DNA断裂の結合に機能的に冗長である

Shan Zha1, Chunguang Guo, Cristian Boboila

  • 1Howard Hughes Medical Institute, The Children's Hospital, the Immune Disease Institute and the Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|December 17, 2010
PubMed
まとめ

ATMとXLFを含む冗長なDNA修復経路は,リンパ球の発達に不可欠です. これらの因子の併合的な欠乏は,V(D) J再結合の際にDNAの末端結合を阻害し,ゲノム不安定を防止する上でそれらの重要な役割を強調する.

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