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Updated: Feb 10, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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グレートウォールは,ミトーシスに不可欠なタンパク質フォスファタゼ2Aの阻害剤をリン酸化します

Satoru Mochida1, Sarah L Maslen, Mark Skehel

  • 1Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

Science (New York, N.Y.)
|December 18, 2010
PubMed
まとめ

新しく開発された経路は,ミトーシス過程でタンパク質フォスファタゼ2A-B55δを阻害する. タンパク質キナーゼグレートウォール (Gwl) はα-エンドスルフィン (Ensa) をリン酸化し,細胞循環制御に不可欠な強力な阻害物質を作り出します.

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