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Updated: Jun 5, 2026

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors
10:17

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Published on: April 29, 2022

グレートウォールキナーゼの基板Arpp19は,タンパク質フォスファタゼ2Aを阻害することによってミトーシスを制御する

Aicha Gharbi-Ayachi1, Jean-Claude Labbé, Andrew Burgess

  • 1Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoléculaire, CNRS UMR 5237, IFR 122, 1919 Route de Mende, 34293 Montpellier cedex 5, France.

Science (New York, N.Y.)
|December 18, 2010
PubMed
まとめ

グレートウォールキナーゼ (Gwl) アクティベーションは,Arpp19とα-Endosulfineをリン酸化することによって,タンパク質フォスファタゼ2A (PP2A) を阻害する. このリン酸化はミトスの侵入を促進し,Arpp19はXenopusの卵抽出物の鍵となる.

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