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阻害の空間的に非対称な再編成は,動きに敏感な回路を確立する
Keisuke Yonehara1, Kamill Balint, Masaharu Noda
1Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
Nature
|December 21, 2010
まとめ
神経回路の発達は,方向的に選択する細胞への阻害的な入力に空間的非対称性を確立します. この急速な発達スイッチは2日間で発生し,ニューロンの処理を形作ります.
科学分野:
- 神経科学は神経科学である.
- 発達生物学 発達生物学とは
- コンピューティング神経科学
背景:
- 神経の接続性は,神経の処理に不可欠な空間的非対称性を表しています.
- 方向選択性 (DS) の網膜のギャングリオン細胞は,スターバーストアマクリン細胞からの非対称的抑制入力に依存しています.
- この回路非対称性を確立する発達メカニズムは,依然としてほとんど不明です.
研究 の 目的:
- スターバースト-DS細胞接続における空間的非対称性の確立の発達タイムラインとメカニズムを調査する.
- 産後発達初期に抑制性インプットアシンメトリーがどのように,いつ発生するかを理解する.
主な方法:
- チャネルロドプシン-2の光刺激により,マウスのスターバースト細胞を標的とした.
- 遺伝的に標識されたDS細胞から記録し,シナプス強度の分布をマッピングする.
- モノシナプス的に制限されたトランスシナプス狂犬病のウイルス追跡で,接続性を確認する.
主要な成果:
- スターバースト-DS細胞の阻害インプットアシンメトリは,2日間で急速に発達します.
- ランダムまたは対称的な接続を持つ中間状態が非対称性の前にあります.
- 発達には,阻害性シナプスインプットの空間的に選択的な再編成が含まれます.
- スターバースト細胞からの刺激的インプットは,阻害的インプットよりも対称性があります.
結論:
- 主細胞回路における対称性から非対称性への抑制的入力分布への急速な発達的な切り替えを示しています.
- 神経発達中のシナプス入力組織のダイナミックな性質を強調しています.
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