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Updated: Jun 5, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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Published on: May 5, 2023

ZRF1によるポリコンブ抑制遺伝子の転写活性化

Holger Richly1, Luciana Rocha-Viegas, Joana Domingues Ribeiro

  • 1Centre de Regulació Genòmica (CRG)/UPF, 08003 Barcelona, Spain.

Nature
|December 24, 2010
PubMed
まとめ

ZRF1タンパク質は,ユビキチン化ヒストンH2Aと結合し,ポリコンブ抑制複合体1 (PRC1) を移動させ,細胞分化中に遺伝子転写を活性化します. この表遺伝的メカニズムは,細胞の運命決定の鍵である.

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