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Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Pre-mRNA Processing: Modification of pre-mRNA Ends01:35

Pre-mRNA Processing: Modification of pre-mRNA Ends

In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps the cell...
Chromatin Structure and RNA Splicing02:41

Chromatin Structure and RNA Splicing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
08:50

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Published on: May 14, 2020

代替的なプレ-mRNAスプライシングにおける表遺伝学

Reini F Luco1, Mariano Allo, Ignacio E Schor

  • 1National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Cell
|January 11, 2011
PubMed
まとめ
この要約は機械生成です。

タンパク質の多様性にとって不可欠な代替スプライシングは,クロマチンの構造のような表遺伝的要因によって規制されていることがますます理解されています. これは,エピジェネティクスが遺伝子発現だけでなく,RNAスプライシングの結果にも影響を及ぼすことを示唆しています.

さらに関連する動画

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells
06:02

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells

Published on: October 28, 2025

関連する実験動画

Last Updated: May 13, 2026

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
08:50

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Published on: May 14, 2020

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells
06:02

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells

Published on: October 28, 2025

科学分野:

  • 分子生物学は分子生物学である.
  • エピジェネティクス エピジェネティクス
  • ゲノミクスゲノミクスとは

背景:

  • 代替スプライシングは,エウカリオットにおけるタンパク質の多様性を生み出す重要なメカニズムである.
  • 伝統的な研究は,RNA要素とスプライシング因子に焦点を当てた.
  • 新興の証拠は,スプライシングの調節におけるクロマチンの構造の役割を強調しています.

研究 の 目的:

  • 染色体構造とヒストンの改変が代替スプライシングに及ぼす影響を調査する.
  • エピジェネティック・レギュレーションを代替スプライシング・コントロールの理解に統合する.

主な方法:

  • RNA配列要素とスプライシング因子の分析.
  • クロマチンの改変がスプライシングパターンに与える影響を調査する.

主要な成果:

  • 染色体構造とヒストンの改変は,代替スプライシングの調節に重要な役割を果たします.
  • エピジェネティックメカニズムは,遺伝子がどのように接合されるかを制御するために不可欠です.

結論:

  • エピジェネティック・レギュレーションは,遺伝子発現を超えて,代替スプライシングに影響を与えます.
  • スプライシングのエピジェネティック制御を理解することは,発達と病気を理解するために不可欠です.