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Updated: Jun 5, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
11:02

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

がん発達の過程で,単一の壊滅的な出来事で得られた大規模なゲノム再編成

Philip J Stephens1, Chris D Greenman, Beiyuan Fu

  • 1Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

Cell
|January 11, 2011
PubMed
まとめ

癌の発症には,クロモトリプシスと呼ばれる突然のゲノム危機があり,多数の再編成が徐々にではなく,一度に起こります. この一度の出来事は,複数の癌のタイプに影響を与え,癌を引き起こす変異に影響を与えます.

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Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing09:49

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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