毛皮の幹細胞,ニッチ,子孫の間のダイナミクス

Ya-Chieh Hsu¹, H Amalia Pasolli, Elaine Fuchs

¹Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

Cell

|January 11, 2011

まとめ

毛皮の幹細胞 (SCs) には,異なる運命があります. 初期の子孫は,新しい髪の成長を開始するために膨らみに戻り,他のものはニッチの居住者になり,マイクロ環境に貢献します.

科学分野:

細胞生物学細胞生物学
幹細胞生物学幹細胞生物学
皮膚科皮膚科について

背景:

毛皮は,幹細胞 (SC) の動態と分化の研究のモデルとして機能しています.
SC系統における不可逆的なコミットメントの正確な点を理解することは,再生医療にとって極めて重要です.

研究の目的:

ヘアフォリクル幹細胞 (HFSCs) に対する不可逆的なコミットメントのポイントを定義する.
ヘアフォリキュルのニッチ内の早期および後半のSCの子孫の運命と機能を調査する.

主な方法:

ヒストンとヌクレオチドのダブルパルスチェイス実験.
系統追跡研究. 系統追跡研究.
浄化,遺伝子発現分析,微分アブレーション,機能実験など.

主要な成果:

初期のSCの子孫は茎を保持し,次の髪のサイクルを開始するために膨らんだニッチに戻ります.
初期膨張SCは,怪我の修復のために予約されています.
逆行不能にコミットした細胞は,幹性を失っても,生き残り,膨らみに戻り,ニッチの微環境に貢献します.

結論:

毛囊には,異なる幹細胞集団と,特異的な役割を持つコミットドプロジェネタが宿っている.
逆戻りなくコミットされた細胞は,幹細胞のニッチ内で重要な機能を獲得することができ,系統のコミットメントの伝統的な見解に挑戦します.

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