ポリコンブグループ体は遺伝子サイレンシングの工場なのか?
Jacob W Hodgson1, Hugh W Brock
1Department of Zoology, University of British Columbia, Vancouver BC, Canada.
Cell
|January 19, 2011
まとめ
ポリコンブ群 (PcG) タンパク質は,ホックス遺伝子を長距離で結合させ,沈黙させるのに役立ちます. この研究は,ホックス遺伝子の核の位置が,PcG媒介による遺伝子静止の鍵であることを示しています.
科学分野:
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
- エピジェネティクス エピジェネティクス
背景:
- ポリコンブ群 (PcG) タンパク質は,遺伝子発現を抑制することが知られているエピジェネティックレギュレータです.
- ホックス遺伝子は発達に不可欠であり,しばしばPcG媒介による抑制の標的となる.
- 長距離クロマチンの相互作用は,遺伝子調節に関与しています.
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