ヒスパニック系における遺伝的リスクスコアと心筋梗塞のリスク
1Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA. nhlqi@channing.harvard.edu
Circulation
|January 19, 2011
まとめ
白人の冠動脈疾患の遺伝マーカーは,ヒスパニック人の心筋梗塞 (MI) リスクと何らかの関連を示しています. 遺伝的リスクスコアは,この集団におけるMI予測をわずかに改善した.
科学分野:
- 遺伝学 遺伝学とは
- 心血管疾患の流行病学について
- 人口遺伝学 人口遺伝学
背景:
- 全ゲノム関連研究 (GWAS) は,ヨーロッパの祖先集団における冠動脈性心疾患 (CHD) に関連した遺伝的局所を特定しました.
- 本研究では,これらの遺伝マーカーのヒスパニック系集団への移植性,特に非致死性急性心筋梗塞 (MI) について調査しています.
研究 の 目的:
- ヒスパニック系コホートにおける急性心筋梗塞 (MI) と以前に特定された白人遺伝的危険因子の関連性を評価する.
- ヒスパニック系におけるMI予測モデルの改善における遺伝的リスクスコアの有用性を評価する.
主な方法:
- コスタリカで症例対照研究が行われ,1989年に最初の非致死性急性心筋梗塞の症例と2096年に人口ベースの対照群を含む.
- 14の単核酸多型体 (SNPs) がゲノタイプ化され,以前は白人の心臓病と関連していたものに焦点を当てました.
- 遺伝的リスクスコアは,トップ3の関連リスクアレルの合計によって開発されました.
主要な成果:
- 3つの独立した場所の7つのSNPは,ヒスパニック系コホートでMIと有意な関連性を示しました.
- 最も強い関連性は,rs4977574 (CDKN2A/2B),rs646776 (CELSR2-PSRC1-SORT1),rs501120 (CXCL12) について観察されました.
- 遺伝的リスクスコアは,臨床予測指標 (P=0.02) に追加されたときにMIの差別を大幅に改善しましたが,受容器操作特性曲線の下の面積の増加は控えめでした (0.67から0.68).
結論:
- MIリスクに対する遺伝的影響は,ヒスパニックと白人の人口の一貫性と格差の両方を示しています.
- 特定された遺伝子マーカーは,ヒスパニック系の人々の間でMIリスクを差別する点でわずかな改善をもたらしています.
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