プラズマβ-アミロイド値と認知準備量の関連は,その後の認知機能低下と関連している
Kristine Yaffe1, Andrea Weston, Neill R Graff-Radford
1Department of Psychiatry, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA. kristine.yaffe@ucsf.edu
JAMA
|January 20, 2011
まとめ
低血β-アミロイド42/40レベルは,認知症のない高齢者の認知機能低下の増加と関連しています. この関連性は,認知準備が低い個体においてより顕著であり,神経変性疾患の潜在的なバイオマーカーを強調しています.
科学分野:
- 神経科学は神経科学である.
- ゲロントロジーはゲロントロジーの学科です.
- バイオマーカーの研究
背景:
- 血β-アミロイド (Aβ) レベルと認知機能低下の関連性について,特に認知症のない高齢者の場合,矛盾する結果があります.
- 以前の研究は,認知症がない場合の認知機能低下よりも,インシデント認知症に焦点を当てていた.
研究 の 目的:
- プラズマのAβ濃度 (Aβ42とAβ42 / 40の比) と,高齢者の9年間の認知機能低下との関連を調査する.
- 認知予備が血のAβレベルと認知低下の関係を変化させるかどうかを判断する.
主な方法:
- Health ABC Studyの997人の黒人と白人のコミュニティに住む高齢者 (平均年齢74.0歳) の見通しによる観察研究.
- 血Aβ42およびAβ42/40のレベルを測定し,10年間にわたり,改変ミニメンタルステート試験 (3MS) を繰り返し使用して認知機能を評価した.
- 関連性を調べ,共変数に調整し,認知準備量 (教育,識字,APOE ε4状態) の測定値との相互作用を評価するために,統計分析を行った.
主要な成果:
- 低血Aβ42/40レベルは,9年間にわたるより大きな認知機能低下と有意に関連していました (P < .001).
- この関連性は,複数の共変数を調整し,インシデント認知症の被験者を除外した後に依然として有意であった.
- 教育,識字,およびAPOE ε4 ステータスを含む認知リザーブの測定は,関連を大幅に変更しました (P = .004 教育,P = .005 識字,P = .02 APOE ε4). 特に,Aβ42/40の低下と認知機能低下の関連性は,認知機能の準備が低い個体においてより強く見られた.
結論:
- 低血Aβ42/40レベルは,認知症のない高齢者の認知能力の低下を9年間にわたって予測する有意な指標である.
- 認知機能低下に対するプラズマAβ42/40の影響は,認知機能の予備によって緩和され,予備が低い個体はより顕著な低下を経験します.
- プラズマAβレベルは,特に認知能力の低下のリスクが高い高齢者を特定するための貴重なバイオマーカーとして役立つ可能性があります.
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