プリントされたGrb10の親アルレルの独特の生理学的および行動的機能
Alastair S Garfield1, Michael Cowley, Florentia M Smith
1Department of Biology & Biochemistry and Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Nature
|January 29, 2011
まとめ
プリントされたGrb10遺伝子は,社会的行動を調節し,脳の父親の表現によって社会的優位性を高めます. 周辺の母体発現の喪失は胎児と胎盤の過剰成長を引き起こします.
科学分野:
- 遺伝学 遺伝学とは
- 神経科学は神経科学である.
- 発達生物学 発達生物学について
背景:
- インプリントされた遺伝子は,単一の親のアレルから発現し,哺乳類の発達と産後機能に不可欠です.
- 不平等な親のアレル表現は,社会的行動を調節するインプリントされた遺伝子の進化を駆動することができます.
- Grb10はインプリントされた遺伝子で,信号伝達経路に関与する細胞内アダプタータンパク質をコードする.
研究 の 目的:
- Grb10の脳内インプリント表現の役割とその社会行動への影響について調査する.
- Grb10が,社会的行動を調節する最初のインプリントされた遺伝子であるかどうかを判断する.
- Grb10の双重組織特異的インプリント表現とその独特の生理学的効果を調査する.
主な方法:
- 胎児から成人期までの脳におけるGrb10発現の分析.
- マウスにおける父性 Grb10 発現の消去.
- 支配とアログルーミングを含む社会的行動の観察と定量化.
- 胎児と胎盤の成長の評価は,母親のGrb10発現の喪失に続いて行われます.
主要な成果:
- Grb10は,脳の発達中および成人期にわたって,脳の父性アレルから発現します.
- 父のGrb10発現の消去は,社会的優位性とアログルーミングの増大につながります.
- 外周的に発現する母親のGrb10アレルの喪失は,胎児と胎盤の著しい過剰成長につながります.
- Grb10は,両方の親アレルから独特の組織特異的なインプリント表現を示しています.
結論:
- Grb10は,社会的行動を調節する最初の識別されたインプリント遺伝子です.
- Grb10は,組織特異的な親性アレル発現を通じて,胎児の成長と成人社会行動を含む,独特の生理学的プロセスに独特の影響を及ぼします.
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