B-DNA,Z-DNA調

Jameson R Bothe1, Ky Lowenhaupt, Hashim M Al-Hashimi

  • 1Department of Chemistry and Biophysics, University of Michigan, Ann Arbor, Michigan 48109, United States.

まとめ

B-DNAからZ-DNAへのDNA構造的移行は,遺伝子調節に不可欠です. この研究では,DNAの柔軟性がZ-DNA形成とB/Z交差点の位置にどのように影響し,CG-リピートが重要な役割を果たすかを明らかにしています.

関連する概念動画

Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
Translesion DNA Polymerases02:10

Translesion DNA Polymerases

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DNA Topoisomerases02:02

DNA Topoisomerases

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Nucleosome Remodeling02:54

Nucleosome Remodeling

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Nucleosome remodeling complex
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DNA Helicases00:55

DNA Helicases

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