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Updated: Jun 4, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
11:42

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

強力な抗ポックスウイルス剤であるシドフォウィルウイルスを含んだDNA複合体の溶液構造

Olivier Julien1, James R Beadle, Wendy C Magee

  • 1Department of Biochemistry, University of Alberta, 4-19 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada.

Journal of the American Chemical Society
|February 2, 2011
PubMed
まとめ

抗ウイルス薬であるシドフォウィール (CDV) はDNAに結合し,DNA複製と合成に影響を与えます. 構造分析により,CDVは容認されているが,DNAの二重複の安定性を低下させ,ダイナミクスの増加を示唆していることが明らかになった.

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