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Updated: Jun 4, 2026

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
11:25

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins

Published on: October 4, 2017

N-グリコシル化逆回転にアロマティックサイドチェーンを配置することによって,タンパク質のネイティブ状態の安定化

Elizabeth K Culyba1, Joshua L Price, Sarah R Hanson

  • 1Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|February 5, 2011
PubMed
まとめ

研究者らは,N-グリコシレーションを用いてタンパク質を安定させる新しい方法を発見した. 特定のアミノ酸配列を追加することで,治療用途のタンパク質の折り畳みと安定性を高めました.

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Rapid Generation of Amyloid from Native Proteins In vitro

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RNA Stability01:53

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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