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Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Updated: Jun 4, 2026

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

ランプレイのチムス候補である.

Baubak Bajoghli1, Peng Guo, Narges Aghaallaei

  • 1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D-79108 Freiburg, Germany.

Nature
|February 5, 2011
PubMed
まとめ
この要約は機械生成です。

ランプレイの幼虫は,T型リンパ球の発達に不可欠な,チモイドと呼ばれるチムス状の構造を持っています. これらのチモイドは,変性リンパ球受容体 (VLR) 遺伝子アセンブリの部位であり,のある脊椎動物におけるチムスの機能に似ています.

さらに関連する動画

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

Two-step Approach to Explore Early- and Late-stages of Organ Formation in the Avian Model: The Thymus and Parathyroid Glands Organogenesis Paradigm
13:43

Two-step Approach to Explore Early- and Late-stages of Organ Formation in the Avian Model: The Thymus and Parathyroid Glands Organogenesis Paradigm

Published on: June 17, 2018

関連する実験動画

Last Updated: Jun 4, 2026

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

Two-step Approach to Explore Early- and Late-stages of Organ Formation in the Avian Model: The Thymus and Parathyroid Glands Organogenesis Paradigm
13:43

Two-step Approach to Explore Early- and Late-stages of Organ Formation in the Avian Model: The Thymus and Parathyroid Glands Organogenesis Paradigm

Published on: June 17, 2018

科学分野:

  • 免疫学 免疫学とは
  • 進化生物学の進化生物学について
  • 脊椎動物学 脊椎動物学

背景:

  • のない脊椎動物 (ウミガメやウミガメ) は,を持つ脊椎動物とは異なるユニークな免疫システムを備えています.
  • ランプレイは,抗原認識のために免疫グロブリンではなく,体的に多様化された変性リンパ球受容体 (VLR) を利用します.
  • のない魚のリンパ球発達の主要なリンパ性臓器は,大部分が特徴化されていないままである.

研究 の 目的:

  • ランプレイにおける一次リンパ性臓器の存在と機能を調査する.
  • T型リンパ球発達の潜在的な部位とVLR遺伝子多様化を特定する.

主な方法:

  • ランプレイの幼虫におけるリンパ上皮質構造の識別と組織学的分析.
  • 特定された構造におけるFOXN1,CDA1,VLRAの遺伝子発現分析.
  • 非機能的なVLRA遺伝子アセンブリの検出.

主要な成果:

  • ティムス状の構造を"ティモイド (thymoids) "と称し,ランプレイの状繊維に識別された.
  • ティモイドはFOXN1,CDA1,VLRAの共発現を示し,T型細胞発達の兆候を示した.
  • 非機能的なVLRA遺伝子組成は,チモイドに多く存在し,VLRの多様化におけるその役割を支持した.

結論:

  • Lamprey thymoidsは,のある脊椎動物における胸腺に類似した主要なリンパ性臓器として機能する.
  • これらの発見は,脊椎動物の系統全体にわたる適応免疫の発達における保存された特徴を強調しています.
  • この研究は,初期の脊椎動物における免疫系進化の理解を深める.