骨髄由来細胞のNotch1は,心筋梗塞後の心臓修復を媒介する
Yuxin Li1, Yukio Hiroi, Soeun Ngoy
1Brigham and Women's Hospital, Cambridge, MA 02139, USA.
Circulation
|February 16, 2011
まとめ
骨髄由来細胞におけるNotch1シグナル伝達は,損傷後の心臓の修復に不可欠である. メゼンキマ幹細胞 (MSC) のNotch1の強化は,心不全性疾患の治療上の利点を提供することがあります.
科学分野:
- 心血管生物学 心血管生物学
- 幹細胞生物学 幹細胞生物学
- 再生医学は,再生医療である.
背景:
- 骨髄 (BM) 由来細胞が傷ついた心臓に採用されるメカニズムは不明である.
- ノッチ受容体は細胞の運命とBM由来細胞機能に影響を与えます.
- 心臓修復のためのBM由来細胞におけるNotch1シグナル伝達の役割は不明である.
研究 の 目的:
- 心筋損傷後の心臓修復を媒介するBM由来細胞におけるNotch1シグナル伝達の役割を調査する.
主な方法:
- Notch1.1.の心臓特異的および全球半導体欠損を有するマウスモデルを使用しました.
- 野生型 (WT) とNotch1欠乏マウス間でBM移植実験を行った.
- 心臓発作のサイズ,心臓機能,新血管化,およびメゼンキマ幹細胞 (MSC) 行動の評価.
主要な成果:
- Notch1 (N1(±)) の全局的半導体欠損は,損傷後の心臓発作のサイズと心臓機能の悪化を意味する.
- WTマウスにN1(±) BMを移植すると,新血管化が減少し,アウトカムが悪化しました.
- N1(±) MSCは,リクルート,増殖,生存率の低下を示し,移植時に心筋損傷の増加につながった.
結論:
- BM由来細胞におけるNotch1シグナル伝達は,効果的な心臓修復に不可欠である.
- BM-derived MSCsにおけるNotch1シグナル伝達を促進する戦略は,心不全性疾患に対する治療的可能性を秘めている.
関連する概念動画
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
01:26Stem Cell Niche
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...