血清ビリルビンと呼吸器疾患と死亡のリスク
Laura J Horsfall1, Greta Rait, Kate Walters
1Research Department of Primary Care and Population Health, University College London, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, England. laura.horsfall@ucl.ac.uk
JAMA
|February 18, 2011
まとめ
健康な成人の血清ビリルビニ濃度の上昇は,慢性閉塞性肺疾患 (COPD) や肺がんを含む呼吸器疾患のリスク低下と,全因死亡率の低下に関連しています.
科学分野:
- 肺内医学 肺内医学 肺内医学
- バイオケミストリー バイオケミストリー
- エピデミオロジー エピデミオロジー
背景:
- 血清の総ビリルビンのレベルは,遺伝的および環境的要因の影響を受けます.
- これらの要因は,個人の呼吸器疾患に対する感受性に影響を与える可能性があります.
研究 の 目的:
- 血清ビリルビンのレベルと呼吸器疾患を発症するリスクとの関連を調査する.
- ビリルビリン濃度と全因死亡率の関係を調べる.
主な方法:
- 504,206人の成人を対象とした大規模なコホート研究では,英国のプライマリケアデータを用いて実施されました.
- 血清ビリルビンのレベルは,肝胆病または血解性疾患のない個体で分析されました.
- 慢性阻害性肺疾患 (COPD),肺がん,全因死亡率の発生率は,20年以上にわたって追跡されました.
主要な成果:
- 高いビリルビニンのレベルは,肺がん,COPD,および全因死亡率の減少と関連しており,男性と女性の両方に見られます.
- ビリルビニンの0.1mg/dLの増加は,肺がんの発生率の8-11%の減少と,男性におけるCOPDの発生率の6%の減少と関連していた.
- 調整された分析では,これらの逆関係が確認され,より高いビリルビン濃度の保護効果を示した.
結論:
- 通常の範囲内で,血清ビリルビンの濃度が高いことは,呼吸器疾患のリスクの低下と相関しています.
- ビリルビンの上昇は,一般の成人の全因死亡率の低下と関連しています.
- これらの発見は,呼吸器疾患と死亡率に対するビリルビンの潜在的な保護的役割を示唆しています.
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