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Updated: Jun 4, 2026

Light-driven Enzymatic Decarboxylation
09:58

Light-driven Enzymatic Decarboxylation

Published on: May 22, 2016

ピルバートデカルボキシラーゼを生物合成の可能性のあるエナンチオセレクティブカルボリガゼに変換する

Danilo Meyer1, Lydia Walter, Geraldine Kolter

  • 1Albrecht-von-Haller-Institute for Plant Sciences and Göttingen Center for Molecular Biosciences, Georg-August-University Göttingen, Ernst-Caspari-Haus, Justus-von-Liebig-Weg 11, D-37077 Göttingen, Germany.

Journal of the American Chemical Society
|February 24, 2011
PubMed
まとめ

エンジニアリングされたピルバートデカルボキシラーゼ (PDC) 変種は,アルデヒド形成よりもカルボリゲーションを100倍好むことを示しています. この生物触媒の設計は, (R) -フェニラセチルカルビノールのような2ヒドロキシケトンの高効率でエナント選択的合成を可能にします.

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Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins10:21

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Published on: June 20, 2019

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