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関連する概念動画

Aquaporins01:25

Aquaporins

Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
Membrane Fluidity01:23

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
SNAREs and Membrane Fusion01:43

SNAREs and Membrane Fusion

Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
Intermolecular Forces03:13

Intermolecular Forces

Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen bonds, and dispersion...
Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...

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関連する実験動画

Updated: Jun 4, 2026

Proof-of-Concept for Gas-Entrapping Membranes Derived from Water-Loving SiO2/Si/SiO2 Wafers for Green Desalination
09:39

Proof-of-Concept for Gas-Entrapping Membranes Derived from Water-Loving SiO2/Si/SiO2 Wafers for Green Desalination

Published on: March 1, 2020

膜のインターフェイスで水の順序付けは,核融合のダイナミクスを制御します.

Peter M Kasson1, Erik Lindahl, Vijay S Pande

  • 1Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.

Journal of the American Chemical Society
|March 1, 2011
PubMed
まとめ

詳細なシミュレーションにより,水は水であることを明らかにしました.

科学分野:

  • バイオフィジックス 生物物理学
  • コンピュータ生物学 コンピュータ生物学
  • マテリアルサイエンス 材料科学

背景:

  • 膜インターフェイスは細胞機能にとって不可欠ですが,その複雑な構成は,基本的な相互作用物理学の理解を複雑にします.
  • 小さな生物系における水の役割は知られていますが,その分子詳細は,大きな膜インターフェースでは無視できるものと考えられていました.
  • 顕微鏡のデータは,膜表面の近くで水の秩序ある行動を示唆し,以前の仮定に疑問を投げかけています.

研究 の 目的:

  • 膜融合とインターフェースにおける化学的詳細,特に水の分子構造の重要性を調査する.
  • 原子解像度のシミュレーションを使用して,膜ダイナミクスにおける水の役割を調査する.

主な方法:

  • 膀融合の原子解像度シミュレーションを実施しました.
  • 水友的な閉じ込め下での膜インターフェイスにおける水の振る舞いを分析した.

主要な成果:

  • 原子解像度のシミュレーションにより,膜融合ダイナミクスに関する洞察が得られた.
  • 膜界面で,水友性の拘束により,水分と異なる,大量にない水の振る舞いを観測した.
  • 膜相互作用における水の化学性質の重要性を強調した.

さらに関連する動画

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy
10:28

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

関連する実験動画

Last Updated: Jun 4, 2026

Proof-of-Concept for Gas-Entrapping Membranes Derived from Water-Loving SiO2/Si/SiO2 Wafers for Green Desalination
09:39

Proof-of-Concept for Gas-Entrapping Membranes Derived from Water-Loving SiO2/Si/SiO2 Wafers for Green Desalination

Published on: March 1, 2020

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy
10:28

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

結論:

  • 水の分子構造は,膜融合とインタフェースのダイナミクスに大きな影響を与えます.
  • 膜界面での水性的な閉じ込めは,ユニークな,非散布水特性を誘発します.
  • 水の化学性質を含む原子レベルの詳細は,膜システムを正確にモデル化するために不可欠です.