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Updated: Jun 4, 2026

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

HDACsは,DNA損傷反応,二重鎖断裂の処理,およびオートファギーをリンクしています

Thomas Robert1, Fabio Vanoli1, Irene Chiolo1,2

  • 1Fondazione IFOM (Istituto FIRC di Oncologia Molecolare), IFOM-IEO Campus, via Adamello 16, Milan 20139, Italy.

Nature
|March 4, 2011
PubMed
まとめ

ヒストン脱酸化酵素 (HDAC) 抑制は,酵母におけるDNA損傷反応経路を阻害し,Mec1 (ATR) の活性化とDNA修復に影響を与えます. このプロセスは,AutophagyによるSae2のアセチル化と分解を伴い,染色体の安定性に影響を及ぼします.

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