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Updated: Jun 4, 2026

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
07:17

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex

Published on: August 2, 2021

SCF (FBW7) は,MCL1を標的とし,その普遍化と破壊を目的として,細胞アポトーシスを調節する

Hiroyuki Inuzuka1, Shavali Shaik, Ichiro Onoyama

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

Nature
|March 4, 2011
PubMed
まとめ

T細胞急性リンパ性白血病 (T-ALL) の腫瘍抑制剤FBW7の喪失は,MCL1の過剰発現につながり,細胞生存を促進します. FBW7を回復させたり,MCL1を枯渇させたりすると,T-ALL細胞が標的治療に再敏感になります.

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