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Updated: Apr 30, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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アンチチューブリン化学療法薬に対する感受性は,MCL1とFBW7によって調節されます

Ingrid E Wertz1, Saritha Kusam, Cynthia Lam

  • 1Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA. ingrid@gene.com

Nature
|March 4, 2011
PubMed
まとめ

生存促進タンパク質MCL1は,抗チューブリン化学療法によって誘発されたアポプトシスを調節する. FBW7によって媒介されるその分解は,細胞死において決定的であり,FBW7の喪失は,これらのがん薬に対する耐性を授与する.

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