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Updated: Jun 3, 2026

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
11:22

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

Published on: June 27, 2018

集積を促進するハンティングチンのN端は,アミロイド繊維の螺旋状である

V N Sivanandam1, Murali Jayaraman, Cody L Hoop

  • 1Department of Structural Biology, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, Pennsylvania 15260, USA.

Journal of the American Chemical Society
|March 9, 2011
PubMed
まとめ

ハンチントンのN末端 (htt(NT)) は,アミロイド核とは異なるヘリックスを形成することによって,ハンチントン病の集積を加速します. このHTTT) ヘリックスは,コア構造に統合することなく,繊維の形成を促進します.

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