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Updated: Jun 3, 2026

Development and Application of Rapamycin-regulated Tyrosine Phosphatases
06:56

Development and Application of Rapamycin-regulated Tyrosine Phosphatases

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タンパク質フォスファタゼ1の調節性サブユニットの選択的抑制は,プロテオスタシスを回復させます

Pavel Tsaytler1, Heather P Harding, David Ron

  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

Science (New York, N.Y.)
|March 10, 2011
PubMed
まとめ

小分子であるグアナベンズは,タンパク質フォスファタゼ1の調節サブユニットを標的とし,タンパク質の折り畳みを回復します. この薬剤候補はeIF2αのリン酸化を延長し,ストレスを受けた細胞をタンパク質の誤折りから救う.

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