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構成的に活性であるロドプシンにおけるアゴニスト誘発活性化の構造的基礎

Jörg Standfuss1, Patricia C Edwards, Aaron D'Antona

  • 1Paul Scherrer Institut, 5232 Villigen PSI, Switzerland.

Nature
|March 11, 2011
PubMed
まとめ

この研究は,Gタンパク質結合受容体 (GPCR) である視覚色素ロドプシンの活性構成を明らかにしています. この発見は,アゴニスト結合がGPCR活性化に必要な重要な形状の変化をどのように引き起こすかを明らかにしています.

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