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Updated: May 12, 2026

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
08:12

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes

Published on: November 1, 2011

B細胞リンパ腫におけるアセチルトランスフェラーゼ遺伝子の不活性化変異

Laura Pasqualucci1, David Dominguez-Sola, Annalisa Chiarenza

  • 1Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA. lp171@columbia.edu

Nature
|March 11, 2011
PubMed
まとめ

遺伝子の活性を調節するCREBBPおよびEP300遺伝子の変異は,小胞性リンパ腫および拡散性大B細胞リンパ腫で一般的です. ヒストンアセチルトランスフェラーゼ (HAT) のこれらの変化がリンパ腫の発症に寄与する.

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