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Updated: Jun 3, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

ラッソペプチドの枠組みにおける配列の多様性:複数のアミノ酸置換による機能的なマイクロシンJ25変異体の発見

Si Jia Pan1, A James Link

  • 1Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, USA.

Journal of the American Chemical Society
|March 12, 2011
PubMed
まとめ

研究者は,機能強化のために,抗微生物ペプチドであるMicrocin J25 (MccJ25) を設計した. 尾部の変異は強力な変異を生み出し,環の変異は活性性を低下させ,ラッソペプチドの構造-機能関係に関する洞察を明らかにした.

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