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アゴニストに結合したヒトA2Aアデノシン受容体の構造

Fei Xu1, Huixian Wu, Vsevolod Katritch

  • 1Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|March 12, 2011
PubMed
まとめ

アデノシンA2A受容体のアゴニストUK-432097と結合した結晶構造は,重要な形状の変化を明らかにします. このアゴニストは,特定の活性状態で受容体を安定させ,Gタンパク質結合受容体シグナル伝達に不可欠です.

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