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Updated: Jun 3, 2026

Isolation of Specific Genomic Regions and Identification of Associated Molecules by enChIP
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Isolation of Specific Genomic Regions and Identification of Associated Molecules by enChIP

Published on: January 20, 2016

TERRAとhNRNPA1は,テロメア単一鎖DNAのRPAからPOT1へのスイッチをオーケストラ化します

Rachel Litman Flynn1, Richard C Centore, Roderick J O'Sullivan

  • 1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

Nature
|March 15, 2011
PubMed
まとめ

テロメア維持には,DNAの複製とシェルターによるキャピングが含まれています. 異質な核リボヌクレオプロテインA1 (hnRNPA1) は,テロメアDNAから複製タンパク質A (RPA) を移動させ,テロメア1 (POT1) の結合を保護し,ゲノム整合性を保ちます.

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Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells09:13

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

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