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哺乳類のAMPKの構造と,ADPによるその調節

Bing Xiao1, Matthew J Sanders, Elizabeth Underwood

  • 1MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

Nature
|March 15, 2011
PubMed
まとめ

アデノシン・ディフォスファート (ADP) がAMP活性化タンパク質キナーゼ (AMPK) に結合すると,そのタンパク質を脱リン酸化から保護し,重要な規制メカニズムを明らかにします. この発見は,細胞のエネルギー状態が生理学的条件下でAMPKの活動をどのように制御するかを説明します.

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