インシデント心血管疾患と睡眠呼吸障害の進行との関連
Hassan A Chami1, Helaine E Resnick, Stuart F Quan
1The Pulmonary Center, Boston University School of Medicine, 72 E Concord Street, Boston, MA 02118, USA.
Circulation
|March 16, 2011
まとめ
新しい心血管疾患 (CVD) イベントは,多様な成人のサンプルで5年間で睡眠障害呼吸の悪化と関連していました. これは,CVDが睡眠時無呼吸症を悪化させ,呼吸器の健康に影響を与える可能性があることを示唆しています.
科学分野:
- 心臓病学 心臓病学
- スリープ・メディシン (睡眠医学)
- エピデミオロジー エピデミオロジー
背景:
- 睡眠による呼吸障害は,心血管疾患 (CVD) の既知の危険因子です.
- CVDが睡眠障害による呼吸に影響を与える潜在的な逆因果関係は,まだ十分に研究されていない.
研究 の 目的:
- インシデント心血管疾患 (CVD) が睡眠呼吸障害の発生または悪化に寄与するかどうかを調査する.
主な方法:
- ベースラインCVDのない2721人の睡眠心臓健康研究参加者のデータを活用した.
- 2つのポリソムノグラムを用いて5年間でアプネア-ヒポポネア指数 (AHI) の変化を評価した.
- 一般的な線形モデルを使用して,インシデントCVDイベント (心筋梗塞,心不全,脳卒中) とAHI変化の関連性を分析した.
主要な成果:
- インシデントCVDを経験した参加者は,CVDのない参加者と比較して,AHIの有意な増加を示しました.
- 調整された平均AHI増加は,インシデントCVDグループでは2.75イベント/時間高かった (P=0.032).
- この関連性は,中央睡眠時無呼吸症を除外した後も,CVDグループで観察された阻害性および中央無呼吸症指数の増加とともに維持されました.
結論:
- インシデント心血管疾患は,5年間の睡眠呼吸障害の悪化と関連しています.
- 研究結果は,中年および高齢者の心血管疾患と睡眠呼吸障害の双方向関係を示唆しています.
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