カテコロアミン受容体のポリモルフィズムが,C. elegansの意思決定に影響する
Andres Bendesky1, Makoto Tsunozaki, Matthew V Rockman
1Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, New York 10065, USA.
Nature
|March 18, 2011
まとめ
Caenorhabditis elegansのパッチを残すような柔軟な餌探し行動は,遺伝的に影響されています. 自然に発生するチラミン受容体3 (ティラ-3) 遺伝子変異は,この決定に影響を与え,行動におけるカテキオラミンの古代の役割を明らかにします.
科学分野:
- 神経科学は神経科学である.
- 遺伝学 遺伝学とは
- 行動生物学 行動生物学
背景:
- 生まれつきの行動には柔軟性があり,環境の変化やゲノム改変に適応します.
- 採食動物にとって極めて重要な探査・採掘の決定は,枯渇する食糧源をいつ離れるかを選択することを含む.
研究 の 目的:
- nematode Caenorhabditis elegans.に食物パッチを残すという決定の遺伝的根拠を調査する.
- この採食行動に影響を与える特定の遺伝子や遺伝的変異を特定する.
主な方法:
- 定量的な遺伝分析は,パッチを残す行動を研究するために使用されました.
- tyra-3遺伝子の自然に発生する非コーディングポリモルフィズムに焦点を当てました.
主要な成果:
- Caenorhabditis elegansのパッチを残す行動は,複雑で多遺伝子的な特徴です.
- チラミン受容体3をコードするタイラ-3で自然に発生するポリモルフィズムが,この行動を部分的に調節する.
- tyra-3は感覚ニューロン内で機能し,外部のシグナルを処理する際に内部カテキオラミンの役割を示しています.
結論:
- 遺伝的多様性と環境のシグナルが,行動を調節するために共有された神経回路に収束します.
- カテコロアミンは,行動的決定の仲介,特に餌を集める文脈において,保存された古代の役割を果たしています.
さらに関連する動画
関連する概念動画
01:27Adrenergic Receptors (Adrenoceptors): Classification
4.9K
Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
4.9K
01:31Adrenergic Receptors: ɑ Subtype
2.7K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
2.7K
01:26Adrenergic Receptors: β Subtype
3.8K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
3.8K
01:16Adrenergic Agonists: Chemistry and Structure-Activity Relationship
3.9K
Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
3.9K
01:21Drugs Affecting Neurotransmitter Release or Uptake
1.8K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.8K
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
81
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
81