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システム生物学の時代における細胞
Paul Nurse1, Jacqueline Hayles
1Cancer Research UK, London Research Institute, 44, Lincoln's Inn Fields, London UK WC2A 3LY, UK. janet.bonner@royalsociety.org
Cell
|March 19, 2011
まとめ
システム生物学は,高スループット技術とコンピューティングモデリングを利用し,新しい生物学的機能と組織的原理を発見しています. このアプローチは,細胞の複雑性とダイナミクスの理解を根本的に再構築しています.
科学分野:
- 細胞生物学 細胞生物学
- システム生物学 システム生物学
- 計算生物学とは,計算生物学である.
背景:
- 高通量技術により,膨大な生物学的データが生成されます.
- コンピューティング・モデリングは,複雑な生物学的システムを分析します.
- これらのアプローチは,生物学的研究を前進させています.
研究 の 目的:
- システム生物学が細胞の見方にどのように影響するかを探求する.
- 新しい生物学的洞察が細胞生物学に与える影響を理解する.
主な方法:
- 高通量実験データの統合.
- 計算モデリング技術の応用.
- 生物学的な機能と組織の分析.
主要な成果:
- 新しい組織レベルでの細胞プロセスの理解が生まれています.
- 細胞システム内の複雑な相互依存関係を特定する.
- 細胞の動的および新興的性質を明らかにする.
結論:
- システム生物学は,細胞のより全体的な見方を提供します.
- このパラダイムシフトは,細胞メカニズムについての理解を深める.
- 細胞生物学における将来の研究方向が再定義されています.
関連する概念動画
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Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
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Non-equilibrium in the Cell
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
The Cell Cycle Control System
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
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Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...

