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関連する概念動画

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

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関連する実験動画

Updated: Jun 3, 2026

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts
06:31

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts

Published on: September 27, 2018

細胞サイクルのモデリング:なぜ特定の回路が振動するのですか?

James E Ferrell1, Tony Yu-Chen Tsai, Qiong Yang

  • 1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA. james.ferrell@stanford.edu

Cell
|March 19, 2011
PubMed
まとめ
この要約は機械生成です。

計算モデリングは,真核細胞の細胞サイクルを自律的な振動器として説明します. この研究は,通常の微分方程式 (ODE) モデルと,Xenopusの胚細胞周期の安定性分析に焦点を当てて,振動的生化学回路を詳細に説明しています.

さらに関連する動画

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

関連する実験動画

Last Updated: Jun 3, 2026

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts
06:31

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts

Published on: September 27, 2018

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

科学分野:

  • バイオケミストリー バイオケミストリー
  • システム生物学 システム生物学
  • コンピュータ生物学 コンピュータ生物学

背景:

  • ユーカリオット細胞サイクル,特にXenopus胚では,振動的行動を示す.
  • 根本的なメカニズムを理解するには,単純な記述を超えた高度な理論的枠組みが必要です.

研究 の 目的:

  • 振動性生化学回路の基本理論を提示する.
  • 計算モデルを用いて,Xenopusの胚細胞サイクルを制御する原理を解明する.

主な方法:

  • ブールのモデル,遅延微分方程式モデル,通常の微分方程式 (ODE) モデルの検討.
  • ODEモデル内のネガティブなフィードバックループと結合されたポジティブ/ネガティブなフィードバック回路の分析.
  • 動的パラメータに基づいて振動的行動を予測するために,線形安定性分析の適用.

主要な成果:

  • 単純なフィードバック回路がODEモデルで振動を生成する方法の実証.
  • 細胞サイクルモデルにおける持続的な振動に必要な条件を特定する.
  • Xenopusの胚細胞周期の動態を捉えるためのODEモデルの検証.

結論:

  • 計算モデリングと非線形動的システム理論は,細胞サイクルメカニズムに関する深い洞察を提供します.
  • 振動性生化学回路は,細胞周期の自律的な動作に不可欠である.
  • 線形安定性分析は,生物オシレータのダイナミックモデルを検証し理解するための重要なツールです.