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関連する概念動画

Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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関連する実験動画

Updated: Jun 3, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

衝動制御:遺伝子転写における時間動態

Nir Yosef1, Aviv Regev

  • 1Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.

Cell
|March 19, 2011
PubMed
まとめ

遺伝子発現パターンは,分子機構を通して刺激に適応する. このレビューでは,遺伝子調節における衝動的,持続的,振動的なパターンに焦点を当てて,時間的ダイナミクスを調査します.

科学分野:

  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは
  • システム生物学 システム生物学

背景:

  • 遺伝子発現の調節は,細胞の適応と機能に不可欠です.
  • 遺伝子発現の時間動態を理解することは,細胞の反応を解読する鍵です.
  • 遺伝子発現のタイミングを形作る分子機構に関する既存の知識は断片化されています.

研究 の 目的:

  • ユカリオットとプロカリオットにおける遺伝子発現の時間的動態をレビューする.
  • 遺伝子発現の原型的な時間的パターンを描写する.
  • これらの時間パターンの基礎にある分子メカニズムを解明する.

主な方法:

  • 遺伝子発現の時間動態に関する研究の文献レビュー.
  • タンパク質回路,シス調節配列,クロマチンの構造を含む分子機構の分析.
  • 衝動反応とその高次元の組織化に焦点を当てる.

主要な成果:

  • 独特の時間的なパターンを特定した:衝動的,持続的,振動的な遺伝子発現.
  • これらの時間パターンを生成するための分子基盤を詳細に説明しました.
  • 核タンパク質回路,プロモーター要素,およびクロマチンの構造の統合を強調した.

さらに関連する動画

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

関連する実験動画

Last Updated: Jun 3, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

結論:

  • 遺伝子発現は,適応に不可欠な多様な時間的動態を示しています.
  • 衝動応答とその組織は,一時的な刺激に対して非常に重要です.
  • 遺伝的および表遺伝的要因の複雑な相互作用が遺伝子発現のタイミングを形作っています.