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Updated: Jun 3, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
12:07

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

S-アデノシルメチオニン依存メチルトランスファーゼの根本的に異なるメカニズム

Tyler L Grove1, Jack S Benner, Matthew I Radle

  • 1Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.

Science (New York, N.Y.)
|March 19, 2011
PubMed
まとめ

ラジカルS-アデノシルメチオニン (SAM) 酵素は,ユニークなピンポンメカニズムを通じて,リボソームRNAの非核性サイトをメチラ化します. これは,システイン残基の中間メチル化を含み,典型的なS(N) 2メチルトランスフェラーゼ反応とは異なる.

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Phase II Reactions: Methylation Reactions

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Transfer RNA Synthesis

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RNA Editing

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Mismatch Repair

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Overview