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Updated: Jun 3, 2026

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
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FASとNF-κBのシグナリングは,肺がんのEGFR変異への依存を調節する

Trever G Bivona1, Haley Hieronymus, Joel Parker

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 20, New York, New York 10065, USA.

Nature
|March 25, 2011
PubMed
まとめ

核因子-カッパB (NF-κB) 経路の阻害は,EGFR変異性肺がんにおけるEGFRチロシンキナーゼ阻害剤 (TKI) の有効性を高める. EGFRと並行してNF-κBをターゲットにすると,肺腺がん患者の治療結果が改善される可能性があります.

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