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Updated: Jun 3, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

ディゴキシンとその誘導体は,RORγt活性に対抗することによって,TH17細胞の分化を抑制する

Jun R Huh1, Monica W L Leung, Pengxiang Huang

  • 1Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.

Nature
|March 29, 2011
PubMed
まとめ

ディゴキシンは,T(H) 17細胞の分化と自己免疫疾患に不可欠なRORγtタンパク質を阻害する. 合成デリバティブは,クローン病やリウマチ性関節炎のような炎症状態を標的とした新しい治療法の開発に希望を示しています.

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